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Updated: Apr 3, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Isolated acquired factor VII deficiency: review of the literature
Sylvie M N Mulliez1, Katrien M J Devreese1
1a Coagulation Laboratory, Department of Clinical Chemistry, Microbiology and Immunology , Ghent University Hospital , Belgium.
Objectives:
Isolated acquired factor VII (FVII) deficiency is a rare haemorrhagic disorder. We report what is currently known about the pathogenesis, clinical features, diagnosis, treatment and prognosis of acquired FVII deficiency.
Methods:
We performed a literature search and included all articles published between 1980 and August 2015.
Results And Conclusions:
Acquired FVII deficiency has been reported in 42 patients. There are well-established clinical diseases associated with acquired FVII deficiency, most notably infections, malignancy and haematological stem cell transplantation. The exact pathogenesis of the diseases is still unknown, but different pathophysiological hypotheses have been suggested. The clinical manifestation of acquired FVII deficiency varies greatly in severity; asymptomatic course as well as severe life-threatening bleeding diathesis and fatal bleedings have been described.
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