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Updated: Apr 3, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Models of disease behavior in idiopathic pulmonary fibrosis
Kerri A Johannson1, Brett Ley2, Harold R Collard3
1Department of Medicine, University of Calgary, 6th Floor - 4448 Front Street S.E., Calgary, AB, T3M-1M4, Canada. kerri.johannson@albertahealthservices.ca.
Abstract:
Idiopathic pulmonary fibrosis is a diffuse parenchymal lung disease of unknown cause. The natural history of disease can vary considerably, making it difficult to predict the clinical trajectory for an individual patient. Accurate prognostication is desirable for clinical management as well as for cohort enrichment in clinical trials of therapeutics. Clinical and biomarker models of disease behavior have been developed to improve prognostication in idiopathic pulmonary fibrosis, with moderate predictive capabilities. Integrated prediction models that combine both clinical and biomarker variables will improve prognostication for patients and improved cohort enrichment strategies for clinical trials. This goal may be best achieved through collaborative patient registries with prospectively collected biological samples that allow for characterization of disease behavior in idiopathic pulmonary fibrosis.
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