Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

870
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
870
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.4K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.4K
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

707
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
707
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

2.1K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.1K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.5K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.5K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

377
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
377

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac adverse events following post-operative radiation therapy in patients with thymic malignancies.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

A structured approach to promote equity in spatial accessibility to TB services during private sector engagement.

IJTLD open·2026
Same author

Yield of a contact investigation among children living with drug-resistant TB patients.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

Impact of normothermic regional perfusion on ex vivo lung perfusion outcomes in donation after circulatory death lung donors.

The Journal of thoracic and cardiovascular surgery·2025
Same author

Adapting a mobile TB screening unit to provide integrated screening services and linkage to primary care.

Public health action·2024
Same author

Outcomes for people with TB by disease severity at presentation.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2024

Related Experiment Video

Updated: Apr 3, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

13.3K

Map the gap: missing children with drug-resistant tuberculosis.

C M Yuen1, C A Rodriguez2, S Keshavjee3

  • 1Brigham and Women's Hospital, Boston, Massachusetts, USA ; Harvard Medical School, Boston, Massachusetts, USA.

Public Health Action
|September 25, 2015
PubMed
Summary

Published literature significantly underrepresents multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) in children. This lack of data hinders advocacy for improved pediatric diagnostics and treatment for drug-resistant TB.

Keywords:
extensively drug-resistant tuberculosismultidrug-resistantpediatrictuberculosis

More Related Videos

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.8K
Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples
06:07

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples

Published on: June 6, 2025

1.5K

Related Experiment Videos

Last Updated: Apr 3, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
07:35

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

13.3K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.8K
Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples
06:07

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples

Published on: June 6, 2025

1.5K

Area of Science:

  • Global Health
  • Infectious Diseases
  • Pediatric Medicine

Background:

  • Limited published data on pediatric multidrug-resistant tuberculosis (MDR-TB) impedes advocacy for better diagnostics and treatment.
  • Lack of recognition of MDR-TB and extensively drug-resistant TB (XDR-TB) in children within scientific literature is a significant global health concern.

Purpose of the Study:

  • To describe the underrepresentation of MDR-TB and XDR-TB in children within the published scientific literature.
  • To highlight the disparity in reporting between adult and pediatric cases of drug-resistant tuberculosis.

Main Methods:

  • Systematic literature search conducted across countries reporting MDR- or XDR-TB cases by 2012.
  • Inclusion criteria focused on identifying published MDR- and XDR-TB cases in both adults and children.

Main Results:

  • Adult MDR-TB cases were reported in 78% of countries, while pediatric MDR-TB cases were reported in only 42%.
  • Adult XDR-TB cases were documented in 60% of reporting countries, contrasted with only 10% for pediatric XDR-TB cases.
  • A substantial gap exists in published data for pediatric drug-resistant TB compared to adult cases.

Conclusions:

  • The absence of publications on childhood MDR- and XDR-TB, where adult cases are reported, suggests exclusion from public health discourse.
  • This underrepresentation likely indicates underdetection of sick children with drug-resistant TB.
  • There is a large-scale lack of awareness regarding children affected by MDR- and XDR-TB globally.