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Related Experiment Videos

The hippocampus and stress induced 17-OHCS elevations.

B R Clower, O J Andy, A M Montalvo

    The Pavlovian Journal of Biological Science
    |April 1, 1979
    PubMed
    Summary

    The hippocampus plays a crucial role in the stress response. Bilateral hippocampal lesions abolish stress-induced elevations in plasma 17-hydroxycorticosteroids (17-OHCS), indicating its importance.

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Stress Physiology

    Background:

    • The limbic system's role in stress response is not fully understood.
    • The hippocampus is a key limbic structure implicated in stress.

    Purpose of the Study:

    • To investigate the hippocampus's specific role in stress-induced plasma 17-hydroxycorticosteroids (17-OHCS) elevations.
    • To determine if hippocampal continuity or steroid binding capacity is essential for the stress response.

    Main Methods:

    • Utilized a conditioned reflex (tone and shock) as a stressor in adult mongrel dogs.
    • Measured plasma 17-OHCS levels using the Porter-Silber method.
    • Assessed the impact of unilateral and bilateral posterior hippocampectomy on 17-OHCS stress response.

    Main Results:

    • Unilateral posterior hippocampal lesions partially attenuated the 17-OHCS stress response by 20%.
    • Bilateral posterior hippocampal lesions completely abolished the 17-OHCS stress response.
    • The stress response depends on the continuity of the hippocampal circuit, not volumetric steroid binding capacity.

    Conclusions:

    • The hippocampus is essential for normal 17-OHCS elevations in response to conditioned stress.
    • Hippocampal circuit continuity is critical for mediating the stress response.
    • A single functioning hippocampus may suffice for physiological stress demands.

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