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Updated: Apr 3, 2026
Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
Published on: February 21, 2015
Development and validation of a diagnostic test for Ridge allele copy number in Rhodesian Ridgeback dogs
Jennifer Turner Waldo1, Kasandra Santana Diaz1
1Biology Department, State University of New York at New Paltz, 1 Hawk Drive, New Palz, NY 12561 USA.
Background:
The breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18. Because this trait is dominant, heterozygous dogs cannot be discriminated from those with two copies of the Ridge allele.
Results:
A quantitative PCR test was developed and dogs of known genotype were used as test subjects. In all cases, the correct genotype was determined experimentally.
Conclusions:
This work provides a rapid and accurate methodology for determining dog genotype with respect to the Ridge allele.
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Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...