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Updated: Apr 3, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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α-Difluoromethylation on sp(3) Carbon of Nitriles Using Fluoroform and Ruppert-Prakash Reagent

Kohsuke Aikawa1, Kenichi Maruyama1, Kazuya Honda1

  • 1Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8552, Japan.

Organic Letters
|September 25, 2015
PubMed

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