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Updated: Apr 3, 2026

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Neurolymphomatosis on 18F-FDG PET/CT: Diagnosis and Therapy Response
Pieterjan Gykiere1, Lennart Jans, Bert Degrieck
1From the Departments of *Nuclear Medicine, †Radiology, and ‡Nuclear Medicine, University Hospital Ghent, Ghent, Belgium.
Abstract:
Neurolymphomatosis represents a peripheral lymphomatous neural infiltration and is a relatively rare condition. Histopathologically, most patients are demonstrated to have non-Hodgkin lymphoma. A 27-year-old man with a history of HLA-B27-positive ankylosing spondylitis and diffuse large B-cell lymphoma was referred for the investigation of a severe neuropathic pain radiating down his right hip and posterior thigh for 1 month. This report describes the diagnosis and therapy response assessment in a relapsing aggressive non-Hodgkin lymphoma on an F-FDG PET scan.
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