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Related Experiment Videos

Chronic vascular catheters in growing piglets.

B W Palmisano1, P S Clifford, R L Coon

  • 1Department of Anesthesiology, Medical College of Wisconsin, Zablocki, VA Medical Center, Milwaukee 53295.

Journal of Developmental Physiology
|December 1, 1989
PubMed
Summary

Chronic vascular catheterization in piglets is challenging due to rapid growth. A novel totally implantable catheter system (Vascular-Access-Port) successfully maintained vascular access in piglets for two months, enabling experimental use in conscious, growing animals.

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Area of Science:

  • Veterinary Medicine
  • Surgical Innovation
  • Animal Research Models

Background:

  • Chronic vascular catheterization in rapidly growing piglets presents significant challenges.
  • Piglet growth rates often lead to catheter dislodgement and experimental complications.
  • Existing methods are often inadequate for long-term vascular access in this model.

Purpose of the Study:

  • To evaluate the efficacy of a totally implantable Vascular-Access-Port system for chronic vascular catheterization in neonatal piglets.
  • To establish a reliable method for long-term drug infusion, blood sampling, and hemodynamic monitoring in growing piglets.
  • To overcome the limitations of traditional catheterization techniques in young, rapidly growing animals.

Main Methods:

  • Surgical implantation of two Vascular-Access-Ports (one venous, one arterial) in ten neonatal piglets (3-7 days old).

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  • Utilizing the ports for drug infusion, arterial blood pressure monitoring, and blood sample collection.
  • Monitoring the piglets for approximately two months, during which they experienced significant body weight gain.

    • Main Results:

    • Successful perioperative survival in nine out of ten piglets.
    • Eight piglets had functional ports for experimental use over the two-month study period.
    • Ports remained patent and functional despite an average eight-fold increase in body weight.

    Conclusions:

    • The Vascular-Access-Port system provides a reliable method for chronic vascular catheterization in conscious, growing piglets.
    • This technique facilitates long-term experimental studies requiring vascular access in neonatal swine.
    • It offers a viable solution to the challenges posed by rapid growth and catheter disruption in piglet models.