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Hepatitis C Virus Infection Associated With an Increased Risk of Deep Vein Thrombosis: A Population-Based Cohort

Chun-Cheng Wang1, Chiz-Tzung Chang, Cheng-Li Lin

  • 1From the Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan (C-CW); Division of Cardiology, Department of Internal Medicine, Taichung Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation (C-CW); College of Medicine, China Medical University (C-TC, C-LL); Division of Nephrology, China Medical University Hospital (C-TC); Management Office for Health Data, China Medical University Hospital, Taichung (C-LL); Department of Family Medicine, Changhua Christian Hospital, Changhua (I-CL); School of Medicine, Chung Shan Medical University, Taichung (I-CL); Department of Nuclear Medicine and PET Center, China Medical University Hospital (C-HK); and Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan (C-HK).

Medicine
|September 25, 2015
PubMed

Insights

Hepatitis C virus (HCV) infection is linked to a higher risk of deep vein thrombosis (DVT), a type of venous thromboembolism (VTE). This study found a significantly increased DVT risk in HCV patients over a long-term follow-up period.

Area of Science:

  • Hepatology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Previous research explored hepatitis C virus (HCV) links to myocardial infarction and stroke.
  • The association between HCV infection and venous thromboembolism (VTE) risk requires further investigation.

Purpose of the Study:

  • To investigate the long-term association between hepatitis C virus (HCV) infection and the risk of venous thromboembolism (VTE), specifically deep vein thrombosis (DVT) and pulmonary embolism (PE).

Main Methods:

  • Utilized the Longitudinal Health Insurance Database 2000 (LHID2000) with 3686 newly diagnosed HCV patients and 14,744 controls.
  • Frequency-matched controls by age, sex, and index year; followed up until 2011.
  • Calculated incidence density rates and hazard ratios (HRs) for DVT and PE.

Main Results:

  • HCV patients had a significantly higher risk of deep vein thrombosis (DVT) (adjusted HR = 1.96; 95% CI = 1.03–3.73).
  • Incidence density rates for DVT were 7.92 per 10,000 person-years in HCV patients versus 3.51 in controls.
  • No significant difference in the risk of pulmonary embolism (PE) was observed between groups.

Conclusions:

  • Hepatitis C virus (HCV) infection is associated with an increased long-term risk of deep vein thrombosis (DVT).
  • Further research may be warranted to explore the mechanisms underlying this association and potential clinical implications.

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