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Prognostic Impact of Blood Pressure Variability on Aortic Dissection Patients After Endovascular Therapy

Lei Zhang1, Wen Tian, Rui Feng

  • 1From the Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China (LZ, WT, RF, CS, ZZ, JB, ZJ); Department of Pharmacology, Second Military Medical University, Shanghai, China (AL, DS); and Department of Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China (JZ).

Medicine
|September 25, 2015
PubMed

Insights

High blood pressure variability (BPV) significantly increases the risk of death in patients with aortic dissection. Understanding BPV is crucial for developing new strategies to prevent and treat this condition.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Clinical Research

Background:

  • Hypertension is a known risk factor for aortic dissection.
  • The prognostic significance of blood pressure variability (BPV) in aortic dissection remains under-investigated.
  • Previous studies have overlooked the impact of BPV on patient outcomes.

Purpose of the Study:

  • To investigate the prognostic significance of preoperative blood pressure variability (BPV) in patients with acute type B aortic dissection.
  • To determine if high BPV is an independent predictor of aorta-related death.
  • To explore the relationship between BPV, hypertension, and false lumen thrombosis.

Main Methods:

  • Retrospective review of 173 patients with acute type B aortic dissection.
  • Stratification of patients into high BPV and low BPV groups based on preoperative mean BPV.
  • Multivariable logistic regression analysis to identify independent predictors of aorta-related death.

Main Results:

  • High BPV was associated with a significantly higher proportion of hypertension and general anesthesia.
  • The risk of aorta-related death was substantially higher in the high BPV group (28.4% vs 9.1%).
  • High BPV was identified as an independent predictor of aorta-related death, with a higher mortality rate regardless of refractory hypertension.

Conclusions:

  • High blood pressure variability (BPV) is an independent risk factor impacting the prognosis of aortic dissection.
  • Elevated BPV is linked to increased aorta-related mortality and poorer outcomes.
  • Further research into BPV may unveil novel preventive and therapeutic strategies for aortic dissection.

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