Related Experiment Video
Updated: Apr 3, 2026
07:36
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
12.0K
First trimester prediction of HELLP syndrome
Natacha Oliveira1, Liona C Poon2, Kypros H Nicolaides2
1Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Prenatal Diagnosis
|September 25, 2015
Summary
First-trimester maternal factors can predict HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Key predictors include ethnicity, nulliparity, prior preeclampsia, prior HELLP, and first-trimester mean arterial pressure.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Perinatal Research
Background:
- HELLP syndrome is a severe pregnancy complication.
- Early identification of pregnancies at risk for HELLP syndrome is crucial for timely intervention.
- First-trimester maternal characteristics and biomarkers are potential predictors.
Purpose of the Study:
- To evaluate first-trimester maternal characteristics and biomarkers for predicting HELLP syndrome.
- To develop and assess a prediction model for HELLP syndrome in early pregnancy.
Main Methods:
- Retrospective comparison of maternal history, biochemical, and biophysical parameters.
- Inclusion of women with HELLP syndrome, preeclampsia without HELLP, and controls.
- Logistic regression analysis to establish a first-trimester prediction model.
Main Results:
- HELLP syndrome was associated with Caucasian ethnicity, nulliparity, and higher first-trimester MAP compared to controls.
- Preeclampsia without HELLP was linked to African-American ethnicity and higher MAP than HELLP.
- A prediction model incorporating ethnicity, nulliparity, prior PE, prior HELLP, and first-trimester MAP achieved an AUC of 0.80.
Conclusions:
- First-trimester prediction of HELLP syndrome is feasible.
- Maternal characteristics and early MAP are significant predictors.
- The developed model demonstrates good predictive performance.
Related Concept Videos
01:07Teratogenicity
4.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
01:27Ovarian Cycle
5.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
5.3K