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Updated: Apr 3, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
[18F]-NaF PET/CT imaging in cardiac amyloidosis
Axel Van Der Gucht1,2,3,4,5, Arnault Galat6,7,8,9,10, Jean Rosso6,7,8,11
1UPEC, AP-HP Henri-Mondor Teaching Hospital, 94000, Créteil, France. axel.vandergucht@gmail.com.
Abstract:
Cardiac amyloidosis (CA) is recognized as a common cause of restrictive cardiomyopathy and heart failure due to the deposition of insoluble proteins in the myocardial interstitium. We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis. We report cases of a 73-year-old man and a 75-year-old woman followed in our center for congestive heart failure with marked alteration of the left ventricular ejection fraction due to familial transthyretin Val122Ile cardiac amyloidosis and light-chain cardiac amyloidosis, respectively, confirmed on endomyocardial biopsy.
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