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Related Concept Videos

Arteries of the Head and Neck01:26

Arteries of the Head and Neck

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The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
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Veins of Head and Neck01:19

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The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
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Related Experiment Video

Updated: Apr 3, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Head and neck soft-tissue sarcoma in adults.

C Galy-Bernadoy1, R Garrel1

  • 1Service d'ORL et de chirurgie cervico-faciale A, CHU-hôpital Gui-de-Chauliac, université Montpellier 1, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.

European Annals of Otorhinolaryngology, Head and Neck Diseases
|September 26, 2015
PubMed
Summary

Adult head and neck soft-tissue sarcoma (HNSTS) is a rare, aggressive cancer. Early diagnosis and specialized multidisciplinary care are crucial for improving the poor prognosis of this challenging disease.

Keywords:
ConticanetDiagnosisHead and neckPrognosisREFCORSoft-tissue sarcomaTreatment

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Medical Genetics

Background:

  • Adult soft-tissue sarcoma (STS) is rare, affecting approximately 5 per 100,000 individuals annually.
  • Head and neck locations are infrequent sites for STS, posing unique diagnostic and therapeutic challenges.
  • Genetic predispositions and prior irradiation are identified risk factors for STS development.

Purpose of the Study:

  • To provide a comprehensive summary of the current knowledge regarding adult head and neck soft-tissue sarcoma (HNSTS).
  • To highlight the importance of accurate diagnosis and understanding of histologic subtypes for effective management.
  • To review established prognostic factors and current treatment strategies for HNSTS.

Main Methods:

  • Review of existing literature on adult head and neck soft-tissue sarcoma.
  • Analysis of diagnostic criteria, including pathologic review and molecular techniques.
  • Evaluation of treatment outcomes and prognostic indicators.

Main Results:

  • HNSTS has a poor prognosis, with a 5-year overall survival rate of approximately 60%.
  • Local recurrence is common, influenced by tumor size, local extension, histologic grade, and margin status.
  • Surgical resection with negative margins is the cornerstone of treatment, often complemented by postoperative radiation therapy.

Conclusions:

  • Accurate diagnosis and classification of HNSTS are essential due to diverse subtypes and prognoses.
  • Multidisciplinary care at reference centers, adhering to national guidelines, is recommended for optimal HNSTS management.
  • Further research is needed to elucidate unknown factors and refine treatment protocols, particularly regarding chemotherapy's role.