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[Impact of visit-to-visit blood pressure variability on vascular function in elderly hypertensive patients]

Qiyun Liu1, Yingying Liu, Junli Han

  • 1Department of Cardiology, Second Affiliated Hospital of Jinan University/Shenzhen People's Hospital, Guangdong Province, Shenzhen 518020, China.E-mail: qyliu7@aliyun.com.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|September 26, 2015
PubMed

Insights

Increased blood pressure variability (BPV) is linked to poorer vascular endothelial function in elderly hypertensive patients. The FMD/NMD ratio better indicates endothelial health than FMD alone.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Endothelial Function Studies

Background:

  • Vascular endothelial dysfunction is a key factor in cardiovascular disease progression.
  • Blood pressure variability (BPV) may reflect subclinical cardiovascular damage.
  • Assessing endothelial function and its relationship with BPV is crucial for managing hypertension.

Purpose of the Study:

  • To investigate the association between visit-to-visit blood pressure variability (BPV) and vascular endothelial function.
  • To compare the efficacy of FMD% and FMD/NMD ratio in assessing endothelial function in elderly hypertensive patients.

Main Methods:

  • 174 elderly hypertensive patients were monitored for 12 months.
  • Office blood pressure (BP) was measured, and brachial artery diameter assessed via flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD).
  • Participants were grouped by FMD/NMD ratio; correlations between BPV and endothelial function were analyzed using regression models.

Main Results:

  • Patients with decreased endothelial function (lower FMD/NMD ratio) exhibited higher BPV and NMD%.
  • A significant negative association was found between the FMD/NMD ratio and BPV, even after adjusting for confounders.
  • Calcium channel blocker use was higher in the normal endothelial function group.

Conclusions:

  • The FMD/NMD ratio is a more sensitive marker of endothelial dysfunction than FMD alone.
  • Elevated visit-to-visit blood pressure variability is associated with impaired endothelial function in elderly hypertensive individuals.
Abstract

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