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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

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Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
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Cholera01:25

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Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
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Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
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The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
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Related Experiment Video

Updated: Apr 3, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
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Escherichia coli - Marauding masquerading microbe.

Amy Lee1, Patrick Coleman2

  • 1Orthopaedic Registrar, Manly Hospital, NSW, Australia.

Journal of Clinical Orthopaedics and Trauma
|September 26, 2015
PubMed
Summary

Escherichia coli is a rare cause of polyarticular septic arthritis (PASA). This case highlights atypical presentations and asymptomatic joint involvement, emphasizing clinical suspicion and nuclear imaging for early diagnosis.

Keywords:
Bone-Gallium scanEscherichia coli sepsisNuclear medicine imagingPolyarticular septic arthritisSeptic arthritis

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Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Orthopedic Surgery

Background:

  • Escherichia coli (E. coli) is an uncommon pathogen in septic arthritis, particularly in its polyarticular form.
  • Polyarticular septic arthritis (PASA) caused by E. coli is exceptionally rare, especially without typical risk factors.

Purpose of the Study:

  • To report an unusual case of E. coli-induced PASA with an atypical presentation.
  • To underscore the importance of clinical suspicion and advanced imaging in diagnosing atypical septic arthritis.

Main Methods:

  • Case report of a patient with E. coli sepsis leading to PASA originating from pyelonephritis.
  • Involved joints included hip, ankle, sternoclavicular, and L5/S1.
  • Treatment involved surgical washout and antibiotics.

Main Results:

  • The patient presented with atypical symptoms, including shoulder pain mimicking shoulder arthritis and initially unrecognized ankle involvement.
  • Nuclear medicine scans were crucial in identifying the extent of joint involvement.
  • The patient recovered mobility after treatment.

Conclusions:

  • Asymptomatic joint involvement can occur in PASA and should be considered in cases of monoarticular septic arthritis (MASA).
  • Early and comprehensive diagnosis of PASA relies on clinical suspicion, especially with atypical pathogens and presentations.
  • Nuclear imaging is recommended for MASA cases where polyarticular involvement is suspected but not clinically evident.