Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005
Jong Won Kim1, Sung-Kyun Ko2, Sangkeun Son2
1Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; College of Pharmacy, Chungbuk National University, Chungbuk 362-763, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|September 26, 2015
Abstract:
During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of 1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of 1 was determined by ROESY and advanced Marfey's method.
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