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Related Experiment Videos

Active and passive immunization against luteinizing hormone in pigs.

B Szafrańska1, A Ziecik

  • 1Institute of Animal Physiology, University of Agriculture and Technology, Ołsztyn-Kortowo, Poland.

Acta Physiologica Hungarica
|January 1, 1989
PubMed
Summary

Active immunization in pigs successfully produced antibodies against porcine luteinizing hormone (pLH), impacting estrous cycles and progesterone levels. This suggests a potential method for controlling reproductive functions in pigs.

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Area of Science:

  • Reproductive Biology
  • Immunology
  • Veterinary Science

Background:

  • Porcine luteinizing hormone (pLH) plays a crucial role in regulating reproductive cycles in pigs.
  • Understanding the effects of modulating pLH activity is essential for reproductive management in swine.

Purpose of the Study:

  • To investigate the efficacy of active immunization against pLH in pigs.
  • To assess the impact of anti-pLH antibodies on estrous cycle length and progesterone concentrations.
  • To evaluate the potential of using anti-pLH antiserum for reproductive control in pigs.

Main Methods:

  • Adult pigs were actively immunized with purified pLH using multi-site intradermal injections.
  • Estrus cycle duration and blood plasma progesterone (P4) levels were monitored.

Related Experiment Videos

  • Anti-pLH pig serum and rabbit anti-pLH globulin were administered to pregnant gilts and gilts in the luteal phase.

    • Main Results:

    • Active immunization led to the production of specific anti-pLH antibodies and prolonged estrous cycles.
    • Administration of anti-pLH pig serum significantly decreased progesterone levels in pregnant gilts and inhibited them in gilts during the luteal phase.
    • Passive immunization with rabbit anti-pLH globulin showed a temporary decrease in progesterone, with levels subsequently increasing.

    Conclusions:

    • Active immunization is a viable method for producing specific anti-pLH antibodies in pigs.
    • The generated antiserum can be effectively used to inhibit corpus luteum function by reducing progesterone levels.
    • This approach holds promise for reproductive management strategies in swine.