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Published on: July 16, 2014
Predictors of Hypomania During Ventral Capsule/Ventral Striatum Deep Brain Stimulation
Alik S Widge1, Ernesto Licon1, Samuel Zorowitz1
1From the Depts. of Psychiatry (ASW, SZ, AC, ARA, JAC, CC, TD, DDD) and Neurological Surgery (ENE), Massachusetts General Hospital and Harvard Medical School, Boston; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge (ASW); and Texas A&M Health Science Center, Bryan (EL).
Abstract:
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.
