Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

4.3K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.3K
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

131
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
131
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.7K
Blood Transfusion01:15

Blood Transfusion

3.0K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piezo1 gain of function induces a platelet preactivation state.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Comprehensive analysis of sickle β<sup>+</sup>-thalassemia genotypes and their associated HbA levels in France.

Blood cells, molecules & diseases·2025
Same author

Hemolytic Anemia With Acanthocytes During Alectinib Treatment of Anaplastic T-Cell Lymphoma: A Case Report and Literature Review.

Journal of pediatric hematology/oncology·2025
Same author

Elevated MCHC reveals a Southeast Asian Ovalocytosis.

American journal of hematology·2023
Same author

Red blood cell proteomics reveal remnant protein biosynthesis and folding pathways in PIEZO1-related hereditary xerocytosis.

Frontiers in physiology·2022
Same author

A Gardos channelopathy associated with nonimmune hydrops and fetal loss.

Clinical genetics·2022

Related Experiment Video

Updated: Apr 3, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.4K

Non-immune Hemolysis: Diagnostic Considerations.

Photis Beris1, Véronique Picard2

  • 1Service d'Hématologie, Département de Médecine Interne, Centre Médical Universitaire Genève Suisse, Geneva, Switzerland; Département d'hématologie, Laboratoire central Unilabs, Coppet, Switzerland.

Seminars in Hematology
|September 26, 2015
PubMed
Summary

Non-immune hemolytic anemia (NIHA) presents with positive hemolytic tests but a negative Coombs test. Diagnosing NIHA requires specialized hematologic evaluation, and this article proposes a diagnostic algorithm.

More Related Videos

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
11:12

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs

Published on: March 9, 2013

35.9K
Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

42.0K

Related Experiment Videos

Last Updated: Apr 3, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.4K
Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
11:12

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs

Published on: March 9, 2013

35.9K
Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

42.0K

Area of Science:

  • Hematology
  • Internal Medicine
  • Pathology

Background:

  • Non-immune hemolytic anemia (NIHA) is defined by positive hemolytic tests and a negative anti-human immunoglobulin (Coombs) test.
  • NIHA encompasses diverse inherited conditions affecting red blood cells and rare thrombotic microangiopathies.
  • Acquired NIHA includes paroxysmal nocturnal hemoglobinuria (PNH), toxic exposures, and hemolysis linked to prosthetic heart valves.

Purpose of the Study:

  • To delineate the spectrum of hereditary and acquired non-immune hemolytic anemias.
  • To highlight the diagnostic challenges in identifying the specific causes of NIHA.
  • To propose a practical algorithm for the etiological investigation of NIHA.

Main Methods:

  • Review of existing literature on non-immune hemolytic anemias.
  • Classification of NIHA into hereditary and acquired categories.
  • Development of a diagnostic algorithm for NIHA investigation.

Main Results:

  • Hereditary NIHA involves erythrocytic enzyme, membrane, or hemoglobin disorders.
  • Acquired NIHA includes PNH, intoxications, and hemolysis related to prosthetic valves.
  • Accurate NIHA diagnosis necessitates specialized hematologic laboratory support.

Conclusions:

  • NIHA is a heterogeneous group of disorders requiring careful diagnostic consideration.
  • A systematic approach, guided by a specialized algorithm, is crucial for identifying NIHA causes.
  • Effective management of NIHA depends on precise etiological diagnosis.