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Roles of competing endogenous RNAs in gastric cancer

Ye Hu, Haiying Tian, Jie Xu

    Briefings in Functional Genomics
    |September 26, 2015
    PubMed

    Insights

    Long noncoding RNAs (lncRNAs) act as competing endogenous RNAs (ceRNAs), regulating gene expression. This review explores the critical roles of ceRNAs in gastric cancer development and progression.

    Area of Science:

    • Molecular Biology
    • Genetics
    • Oncology

    Background:

    • Long noncoding RNAs (lncRNAs), initially considered transcriptional noise, are now recognized for their regulatory functions in biological processes.
    • Emerging evidence highlights the involvement of noncoding genes in the complex pathogenesis of gastric cancer.
    • The competing endogenous RNA (ceRNA) network, involving interactions between lncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs), represents a novel layer of gene regulation.

    Purpose of the Study:

    • To review and synthesize recent findings on the function of ceRNAs in the context of gastric carcinogenesis.
    • To elucidate the significance of the lncRNA-miRNA interaction in gastric cancer development.

    Main Methods:

    • Literature review of recent studies investigating ceRNA mechanisms in gastric cancer.
    • Analysis of lncRNA and miRNA expression patterns and their interactions in gastric cancer datasets.
    • Functional studies examining the impact of ceRNA dysregulation on cancer cell behavior.

    Main Results:

    • lncRNAs can function as ceRNAs by sequestering miRNAs, thereby modulating the expression of miRNA target genes.
    • Dysregulation of specific lncRNA-miRNA-mRNA ceRNA axes has been implicated in various aspects of gastric carcinogenesis, including proliferation, invasion, and metastasis.
    • The ceRNA network offers a complex regulatory landscape contributing to gastric cancer initiation and progression.

    Conclusions:

    • ceRNAs play a significant role in the intricate regulatory network of gastric cancer.
    • Understanding ceRNA mechanisms provides novel insights into gastric cancer pathogenesis.
    • ceRNAs represent potential therapeutic targets for gastric cancer treatment.
    Keywords:
    competing endogenous RNAgastric cancerlong noncoding RNAmicroRNA binding sites

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