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Related Concept Videos

Sympathetic Signaling01:31

Sympathetic Signaling

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Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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The Sympathetic Nervous System01:25

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TGF - β Signaling Pathway01:16

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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Sympathetic Pathways: Sympathetic Chain Ganglia01:20

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The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
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Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

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The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
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Related Experiment Video

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Whole-mount Imaging of Mouse Embryo Sensory Axon Projections
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TrkB/BDNF signalling patterns the sympathetic nervous system.

Jennifer C Kasemeier-Kulesa1, Jason A Morrison1, Frances Lefcort2

  • 1Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA.

Nature Communications
|September 26, 2015
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Summary
This summary is machine-generated.

The sympathetic nervous system

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neurobiology

Background:

  • The sympathetic nervous system is vital for mammalian homeostasis.
  • The development of sympathetic ganglia, particularly their dorsal migration, is not fully understood.
  • Sympathetic ganglia form from primary ganglia that migrate dorsally to meet preganglionic neurons.

Purpose of the Study:

  • To investigate the developmental process of sympathetic ganglia migration.
  • To elucidate the cellular and molecular mechanisms underlying the dorsal migration of sympathetic ganglia.
  • To understand the role of neuron-neuron interactions in patterning the peripheral nervous system.

Main Methods:

  • Investigated the dorsal migration of sympathetic ganglia in vivo.
  • Utilized techniques to assess cell migration and neuronal interactions.
  • Examined the involvement of specific signaling pathways, including BDNF/TrkB.

Main Results:

  • Dorsal migration of sympathetic ganglia is a choreographed process, not individual cell movement.
  • Migration requires contact between pre- and post-ganglionic neurons.
  • BDNF/TrkB signaling mediates the chemotactic guidance of sympathetic neurons by preganglionic axons.

Conclusions:

  • Preganglionic axons guide sympathetic ganglia migration through BDNF/TrkB signaling.
  • This interaction is crucial for the proper patterning of the developing peripheral nervous system.
  • Sympathetic nervous system development relies on precise neuronal communication and migration guidance.