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Related Experiment Videos

[Lymphocyte imbalance in autoimmunity].

J A Manni, C Guilleron, H A Araujo

    Medicina
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Systemic Lupus Erythematosus (SLE) patients show increased CD5+ B cells forming mouse erythrocyte rosettes (MRBC). These cells and associated autoantibodies may indicate disease severity and dysfunction in SLE and leprosy.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Autoimmunity

    Context:

    • A subset of normal peripheral B lymphocytes expresses a T-cell surface antigen recognized by monoclonal CD5, forming rosettes with mouse erythrocytes (MRBC).
    • These CD5+ B cells are implicated in regulatory and helper functions.
    • Previous research suggests a potential role for these cells in autoimmune conditions.

    Purpose:

    • To investigate the prevalence of MRBC-forming lymphocytes in Systemic Lupus Erythematosus (SLE) patients.
    • To correlate MRBC levels with disease severity.
    • To characterize the cell surface antigens and autoantibody profiles associated with MRBC formation in SLE and leprosy.

    Summary:

    • An expanded subset of MRBC-forming lymphocytes was found in SLE patients (14.4%) compared to healthy controls (4.3%) and tuberculosis patients (6.4%), correlating with disease severity.

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  • Monoclonal antibodies against CD5, CD3, and CD8 completely inhibited MRBC formation, while anti-Ia showed partial inhibition.
  • Lymphocytotoxic antibodies inhibiting MRBC formation were detected in 87% of SLE patients and 57% of leprosy patients, with non-specific reactivity to T and B cells.

    • Impact:

    • This study identifies a specific lymphocyte subset and associated autoantibodies as potential biomarkers for SLE and leprosy.
    • Findings contribute to understanding the immunopathogenesis of SLE and related autoimmune disorders.
    • Highlights the role of T-cell antigen-expressing B cells in autoimmune disease activity.