Related Experiment Video
Updated: Apr 3, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a
Changwoo Han1, Hwallip Bae2, Sung-Doo Won3
1Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Ansan, Korea.
Background:
As a neurotoxic substance, alcohol can induce neurodegenesis in the brain. Alcohol-dependent patients' cognitive functioning can be affected by chronic alcohol use. In addition, brain-derived neurotrophic factor (BDNF) is known to reflect the status of neuroadaptive changes. The purpose of this study was to investigate the relationship between cognitive functions and BDNF in alcohol-dependent patients.
Methods:
The subjects were 39 alcohol-dependent patients. BDNF was measured using an enzyme-linked immunosorbent assay kit. We examined clinical features and administered the Korean version of Alcohol Dependence Scale. We also used the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) to measure cognitive functioning. Then, we determined the relationships between BDNF and various parts of the CERAD.
Results:
The performance of alcohol-dependent patients proved stable in most parts of the CERAD. Within the different parts of the CERAD, only Trail Making Test B correlated with BDNF. Trail Making Test specifically assesses executive functions.
Conclusions:
BDNF might play an important role in the detection of neurocognitive function among individuals with alcohol dependence.
More Related Videos
19:57The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
09:50Experimental Methods for Testing the Effects of Neurotrophic Peptide, ADNF-9, Against Alcohol-induced Apoptosis during Pregnancy in C57BL/6 Mice
Published on: April 24, 2013
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
The Blood-brain Barrier
Role of Neurotransmitters in Memory
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Gut-Brain Axis
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists