A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP/PRSS16 involved in CD4+ T-cell maturation
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Updated: Apr 3, 2026

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
Published on: August 9, 2019
Lydie Brisson1, Alice Carrier1
1Inserm; U1068; CRCM ; Marseille, France ; Institut Paoli-Calmettes ; Marseille, France ; Aix-Marseille Université ; Marseille, France ; CNRS; UMR7258; CRCM ; Marseille, France.
Abstract:
The maturation of a specific subset of CD4+ T lymphocytes in the thymus is dependent on cortical thymic epithelial cells expressing the protease thymus-specific serine protease (TSSP, also known as PRSS16). Recently, we unveiled the involvement of TSSP in tumor suppression through its effect on the CD4+ T compartment.
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