Effect of Different Psychoactive Substances on Serum Biochemical Parameters

Area of Science:

• Clinical Biochemistry
• Toxicology
• Addiction Medicine

Background:

• Psychoactive substances profoundly impact the central nervous system and behavior.
• Understanding these effects on physiological parameters is crucial for managing substance dependence.

Purpose of the Study:

• To investigate the impact of various psychoactive substances on serum biochemical profiles.
• To establish correlations between substance use and specific biochemical alterations.

Main Methods:

• A cohort of 324 individuals with psychoactive substance dependence and 69 controls were analyzed.
• Biochemical parameters and urine toxicology were assessed, excluding participants with comorbidities.
• Statistical analysis identified significant differences between dependent and control groups.

Main Results:

• Significant differences were observed in Gamma-Glutamyl Transferase (GGT), uric acid, creatinine, urea, albumin, and Aspartate Aminotransferase (AST) between groups.
• Opium and benzodiazepine dependence showed distinct alterations in sodium, albumin, urea, glucose, and T protein levels.
• Ethyl glucuronide dependence was associated with changes in triglyceride and GGT levels.

Conclusions:

• Routine serum biochemistry can serve as an indicator for intensive monitoring in psychoactive substance dependents.
• Identifying specific biochemical changes aids in tailoring treatment and management strategies.
• This study underscores the systemic effects of psychoactive substance use on the body.