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A Practical Guide to Phylogenetics for Nonexperts
Published on: February 5, 2014
A comparative analysis of multiple sequence alignments for biological data
Umar Manzoor1, Sarosh Shahid2, Bassam Zafar1
1Faculty of Computing and Information Technology, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract:
Multiple sequence alignment plays a key role in the computational analysis of biological data. Different programs are developed to analyze the sequence similarity. This paper highlights the algorithmic techniques of the most popular multiple sequence alignment programs. These programs are then evaluated on the basis of execution time and scalability. The overall performance of these programs is assessed to highlight their strengths and weaknesses with reference to their algorithmic techniques. In terms of overall alignment quality, T-Coffee and Mafft attain the highest average scores, whereas K-align has the minimum computation time.
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