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Excessive Weight Gain during the First Year of Peritoneal Dialysis Is Associated with Inflammation, Diabetes
Jwa-Kyung Kim1, Young-Su Kim1, Young Rim Song1
1Department of Internal Medicine, Kidney Research Institute, Hallym University Sacred Heart Hospital, Hallym University, Anyang, Korea.
Plos One
|September 26, 2015
Summary
Excess weight gain in the first year of peritoneal dialysis (PD) is linked to faster loss of residual renal function (RRF). Managing body weight is crucial for preserving kidney function in PD patients.
Area of Science:
- Nephrology
- Renal Medicine
- Dialysis
Background:
- Weight gain is common in peritoneal dialysis (PD) patients.
- The clinical impact of this weight gain on kidney function is not well understood.
Purpose of the Study:
- To investigate the effect of excess weight gain within the first year of PD on residual renal function (RRF).
Main Methods:
- A longitudinal observational study of 148 incident PD patients.
- Residual renal function (RRF) and body weight (BW) were measured over 2-3 years.
- Excess weight gain was defined as BW increase > 3.0% from baseline.
Main Results:
- Patients with >3.0% BW gain showed significantly faster RRF decline (p<0.001).
- BW increase correlated with inflammation (hs-CRP) and RRF decline.
- Excess BW gain increased the risk of RRF loss by 4.17-fold.
Conclusions:
- Excess weight gain in the first year of PD is associated with systemic inflammation, diabetes, and accelerated RRF decline.
- Weight management is important for preserving kidney function in PD patients.
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