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Related Experiment Video

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The Forced Swim Test as a Model of Depressive-like Behavior
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hTERT genetic variation in depression.

Ya Bin Wei1, Lina Martinsson2, Jia Jia Liu3

  • 1Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Journal of Affective Disorders
|September 26, 2015
PubMed
Summary
This summary is machine-generated.

Shorter telomere length (TL) in saliva DNA is linked to depression. The hTERT gene variant rs2736100 is associated with depression and bipolar disorder episodes, suggesting a role for hTERT in mood disorders.

Keywords:
Bipolar disorderDepressive episodeSalivaSingle nucleotide polymorphismTelomeraseTelomere

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Area of Science:

  • Genetics
  • Molecular Biology
  • Psychiatry

Background:

  • Telomeres (TL) are protective DNA complexes at chromosome ends, with length varying by tissue.
  • Shorter leukocyte telomere length (LTL) is linked to depression and childhood adversity.
  • Salivary DNA TL studies are less common, and telomerase (hTERT) counteracts shortening.

Purpose of the Study:

  • To investigate if salivary DNA TL is shorter in adults with a history of depression.
  • To determine the role of the hTERT polymorphism rs2736100 in depression and bipolar disorder type 1 (BD1).

Main Methods:

  • Saliva TL was measured using qRT-PCR in 662 age-matched depressed individuals and controls.
  • rs2736100 polymorphism was genotyped in 436 depressed individuals, 1590 controls, and 368 BD1 patients.
  • Participants were from a population-based cohort, with BD1 patients diagnosed by psychiatrists.

Main Results:

  • Depressed individuals exhibited shorter salivary TL compared to controls.
  • The rs2736100 minor allele correlated with depression in individuals without childhood adversity.
  • This allele was also associated with the number of depressive episodes in BD1 patients responding to lithium.

Conclusions:

  • This study is the first to examine hTERT genetic variation in mood disorders.
  • Genetic variations in hTERT may contribute to depression susceptibility.
  • Findings suggest a potential link between telomere length, hTERT genetics, and mood disorders.