Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

716
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
716
The Skin Microbiota01:27

The Skin Microbiota

53
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
53
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

50
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
50
Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

52
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
52
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

76
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
76
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin D supplementation in primary hyperparathyroidism: effects on 1,25(OH)<sub>2</sub> vitamin D and FGF23 levels.

Journal of endocrinological investigation·2024
Same author

Lactobacillus delbrueckii UFV-H2b20 increases IFN-Îł production and CD39<sup>+</sup>CD73<sup>+</sup> Treg cell numbers in lungs, and protects mice against experimental allergic asthma.

Immunobiology·2022
Same author

Regulation of macrophage subsets and cytokine production in leishmaniasis.

Cytokine·2020
Same author

Exploring the inquiry-based learning structure to promote scientific culture in the classrooms of higher education sciences.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology·2019
Same author

Effect of ethylenediaminetetraacetic acid irrigation on immune-inflammatory response in teeth submitted to regenerative endodontic therapy.

International endodontic journal·2019
Same author

Immunological profile of teeth with inflammatory periapical disease from chronic liver disease patients.

International endodontic journal·2018

Related Experiment Video

Updated: Apr 3, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
06:57

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

8.8K

Indigenous microbiota and Leishmaniasis.

M E M Lopes1, M B H Carneiro1, L M Dos Santos1

  • 1Departamento de BioquĂ­mica e Imunologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Parasite Immunology
|September 26, 2015
PubMed
Summary
This summary is machine-generated.

The gut microbiota influences Leishmania infection outcomes in mice. Understanding this host-microbiota interaction is crucial for managing leishmaniasis, a significant global health issue.

Keywords:
Leishmania amazonensisLeishmania majorgermfree miceleishmaniasismicrobiota

More Related Videos

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites
10:01

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites

Published on: March 16, 2018

11.1K
In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
09:53

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

16.7K

Related Experiment Videos

Last Updated: Apr 3, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
06:57

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

8.8K
Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites
10:01

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites

Published on: March 16, 2018

11.1K
In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
09:53

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

16.7K

Area of Science:

  • Microbiology
  • Immunology
  • Parasitology

Background:

  • The human body hosts a vast indigenous microbiota, particularly in the gut, playing a key role in host physiology.
  • Germfree animal models are essential for studying microbiota-host interactions, revealing varied susceptibility to pathogens.
  • Leishmaniasis, a widespread parasitic disease, has a poorly understood relationship with the host's indigenous microbiota.

Purpose of the Study:

  • To review and discuss the influence of the indigenous microbiota on the outcome of experimental cutaneous leishmaniasis in murine models.
  • To highlight current knowledge gaps regarding microbiota's role in Leishmania infection.

Main Methods:

  • Literature review focusing on studies utilizing murine models of cutaneous leishmaniasis.
  • Analysis of data investigating the impact of microbiota on disease progression and host response.

Main Results:

  • The indigenous microbiota can modulate host susceptibility or resistance to Leishmania infection.
  • Specific microbial compositions may influence the clinical manifestations of leishmaniasis.

Conclusions:

  • The host microbiota is a significant factor affecting leishmaniasis outcomes.
  • Further research is needed to elucidate the mechanisms by which the microbiota impacts Leishmania infection and to explore therapeutic potential.