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Updated: Apr 3, 2026
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Invasive Fusariosis: A Single Pediatric Center 15-Year Experience
Kevin L Schwartz1, Holden Sheffield2, Susan E Richardson3
1Division of Infectious Diseases, Department of Pediatrics.
Abstract:
Invasive fungal infection (IFI) is an important cause of mortality in immunocompromised children, particularly after hematopoietic stem cell transplantation. We describe 5 cases of Fusarium IFI in immunocompromised children seen at our institution over a 15-year period. A summary of all published pediatric cases of invasive Fusarium infection is presented. A focus on antifungal management challenges in these patients will be discussed.
Insights
Invasive fungal infections (IFIs) pose a significant mortality risk in immunocompromised children, especially post-stem cell transplant. This study details Fusarium IFIs in pediatric cases, highlighting antifungal treatment challenges.
Area of Science:
- Pediatric Hematology
- Infectious Diseases
- Mycology
Background:
- Invasive fungal infections (IFIs) are a major cause of mortality in immunocompromised children.
- Hematopoietic stem cell transplantation (HSCT) increases the risk of IFIs in this population.
Purpose of the Study:
- To describe cases of Fusarium invasive fungal infections (IFIs) in immunocompromised children.
- To summarize published pediatric cases of invasive Fusarium infections.
- To discuss challenges in antifungal management for these patients.
Main Methods:
- Retrospective case series of 5 patients with Fusarium IFI at a single institution over 15 years.
- Literature review to compile published pediatric Fusarium IFI cases.
- Analysis of antifungal treatment strategies and outcomes.
Main Results:
- Five cases of Fusarium IFI in immunocompromised children were identified.
- A comprehensive summary of existing pediatric Fusarium IFI literature was compiled.
- Antifungal management presented significant challenges.
Conclusions:
- Fusarium IFI is a serious concern in immunocompromised children, particularly post-HSCT.
- Effective antifungal strategies for pediatric Fusarium IFI require further investigation.
- Multidisciplinary approaches are crucial for managing these complex infections.
