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Linezolid-Associated Thrombocytopenia in Children With Renal Impairment

Sara J Jones1, Kristen R Nichols2, Heather L DeYoung3

  • 1Department of Pharmacy, Lutheran Hospital, Fort Wayne, Indiana;

Journal of the Pediatric Infectious Diseases Society
|September 26, 2015
PubMed

Insights

Children receiving linezolid with impaired renal function, indicated by lower creatinine clearance, face an increased risk of thrombocytopenia. This finding highlights the importance of monitoring platelet counts in pediatric patients with kidney issues during linezolid treatment.

Area of Science:

  • Pediatric Nephrology
  • Pharmacology
  • Hematology

Background:

  • Linezolid is an antibiotic used for serious infections.
  • Thrombocytopenia (low platelet count) is a known risk associated with linezolid in adults.
  • Impaired renal function is a potential risk factor for adverse drug reactions.

Purpose of the Study:

  • To investigate the association between renal function and the risk of thrombocytopenia in pediatric patients receiving linezolid.
  • To determine if creatinine clearance is a predictor of linezolid-induced thrombocytopenia in children.

Main Methods:

  • Retrospective cohort study design.
  • Analysis of pediatric patients treated with linezolid.
  • Assessment of renal function using creatinine clearance.
  • Evaluation of platelet counts and incidence of thrombocytopenia.

Main Results:

  • A significant association was observed between lower creatinine clearance and the development of thrombocytopenia in children on linezolid.
  • This finding suggests impaired renal function is a risk factor for thrombocytopenia in pediatric linezolid users.
  • The data supports previous observations in adult populations.

Conclusions:

  • Pediatric patients with reduced kidney function are at higher risk for thrombocytopenia when treated with linezolid.
  • Monitoring platelet counts is crucial in children with impaired renal function receiving linezolid.
  • Further prospective studies may be warranted to confirm these findings.

Keywords:
childrenlinezolidpediatricrenal impairmentthrombocytopenia

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