Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Organization01:24

Protein Organization

10.0K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
10.0K
Protein-protein Interfaces02:04

Protein-protein Interfaces

15.0K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
15.0K
Protein Families02:47

Protein Families

17.5K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
17.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytochrome P450-Mediated Metabolism of Antimycobacterial <i>N</i>α-Aroyl-<i>N</i>-aryl-phenylalanine Amides.

ACS infectious diseases·2026
Same author

Efficient NK cell transduction with VSV-G-pseudotyped lentiviral vectors.

Molecular therapy. Advances·2026
Same author

Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate.

Science (New York, N.Y.)·2026
Same author

ProteoGyver: a fast, user-friendly tool for routine QC and analysis of MS-based proteomics data.

Bioinformatics (Oxford, England)·2026
Same author

`3-Hydroxy-6H,7H-chromeno [3,4-c]chromene-6,7-dione as a Substrate for Studying Glucuronidation, Sulfonation and Lactone Hydrolysis.

Drug metabolism and bioanalysis letters·2026
Same author

Canine parvovirus infection affects host cell nucleolar organization and ribosome biogenesis.

Communications biology·2026

Related Experiment Video

Updated: Apr 3, 2026

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

13.8K

Ultrafast protein structure-based virtual screening with Panther.

Sanna P Niinivehmas1, Kari Salokas1,2, Sakari Lätti1,2

  • 1Department of Biological and Environmental Science & Nanoscience Center, University of Jyvaskyla, P.O. Box 35, 40014, University of Jyvaskyla, Finland.

Journal of Computer-Aided Molecular Design
|September 27, 2015
PubMed
Summary

Panther is a new ultrafast docking tool that accelerates virtual screening by creating a protein binding site model. This method processes ligands in under a second, significantly speeding up drug discovery.

Keywords:
Molecular dockingPantherSimilarity searchVirtual screening

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.7K

Related Experiment Videos

Last Updated: Apr 3, 2026

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

13.8K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.7K

Area of Science:

  • Computational chemistry
  • Structural biology
  • Drug discovery

Background:

  • Protein structure-based virtual screening is crucial for drug discovery.
  • Current molecular docking methods are often time-consuming.

Purpose of the Study:

  • Introduce Panther, a novel, ultrafast, multipurpose docking tool.
  • Demonstrate Panther's efficiency and broad applicability.

Main Methods:

  • Utilize protein crystal structures to create a shape-electrostatic model of the ligand-binding site.
  • Employ a similarity search algorithm to compare ligand features against the protein model.
  • Develop an ultrafast docking protocol.

Main Results:

  • Panther processes individual ligands in under 1 second, compared to minutes for classical methods.
  • The tool enables rapid screening of large chemical libraries.

Conclusions:

  • Panther significantly accelerates early-stage drug discovery projects.
  • The tool can aid in reducing clinical trial failures and assessing chemical environmental toxicity.