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Development of the Oral Microbiota01:28

Development of the Oral Microbiota

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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
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Related Experiment Video

Updated: Apr 3, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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Invited commentary: isolating preterm birth to assess its impact.

David A Savitz, Erika F Werner

    American Journal of Epidemiology
    |September 27, 2015
    PubMed
    Summary

    Trauma-related preterm births show newborns face significant health risks. This suggests that the underlying causes of preterm birth may be less impactful than the early delivery itself.

    Area of Science:

    • Neonatal Health
    • Perinatal Epidemiology
    • Obstetrics

    Background:

    • Differentiating the effects of early delivery from its causes on neonatal outcomes is complex.
    • Pathologies leading to preterm birth often involve stressful uterine environments and allow for interventions.
    • Trauma-related preterm births present a unique model to study the impact of delivery timing.

    Purpose of the Study:

    • To assess the health risks associated with trauma-related preterm births.
    • To understand the independent impact of preterm birth on neonatal health outcomes.
    • To evaluate the influence of delivery antecedents versus delivery timing.

    Main Methods:

    • Analysis of neonatal health outcomes in trauma-related preterm births.
    • Comparison of outcomes between trauma-related and pathology-related preterm births.
    Keywords:
    infant healthpreterm birthtrauma

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  • Epidemiological assessment of risk factors and outcomes.

    • Main Results:

    • Trauma-related preterm births are associated with substantially increased risks of adverse neonatal health outcomes.
    • Findings suggest that the underlying pathology may have a less significant independent effect than previously thought.
    • A longer gestational period appears beneficial for neonatal outcomes, irrespective of the cause of preterm birth.

    Conclusions:

    • Preterm birth, independent of its usual pathological causes, poses significant risks to neonatal health.
    • The timing of delivery and fetal maturation/intervention opportunities are critical factors.
    • Further research into the independent effects of preterm birth is warranted.