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Fatigue in Parkinson's disease and potential interventions
Neurorehabilitation
|September 28, 2015
Summary
Fatigue is a common and progressive symptom in Parkinson's disease (PD). Current treatments are limited, but pilot studies suggest potential benefits from medications like Levodopa and exercise programs.
Area of Science:
- Neurology
- Movement Disorders
Background:
- Fatigue is a prevalent and progressive non-motor symptom in Parkinson's disease (PD) impacting patient quality of life.
- It is associated with other symptoms like apathy, depression, sleep disorders, and cognitive dysfunction.
Purpose of the Study:
- To review the measurement and pathophysiology of fatigue and fatigability in Parkinson's disease.
- To explore pilot studies on potential pharmacological and exercise-based interventions.
Main Methods:
- Literature review of fatigue assessment tools and pathophysiological mechanisms.
- Analysis of pilot studies on pharmacological agents (e.g., Levodopa, modafanil) and exercise interventions.
Main Results:
- Fatigue Severity Scale, Multidimensional Fatigue Inventory, and Parkinson Fatigue Scale assess fatigue severity.
- Finger tapping, force generation, and reaction time paradigms quantify physical and cognitive fatigability.
- Physical fatigability correlates with cortical excitability changes; cognitive fatigability links to neurotransmitter abnormalities.
Conclusions:
- No definitive evidence-based treatments currently exist for Parkinson's disease fatigue and fatigability.
- Pharmacological agents (Levodopa, modafanil, methylphenidate, rasagiline) and exercise programs show promise in pilot studies.
- Further large-scale clinical trials are needed to establish effective treatments.
Keywords:
Attention Network TestParkinson’s diseaseexercisefatigabilityfatigueforce generationmethylphenidatemodafinilrasagilineMore Related Videos
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