Incidental risk for diabetes according to serum ferritin concentration in Korean men
Sunyong Kim1, Sung Keun Park2, Jae-Hong Ryoo3
1Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background:
Despite accumulating evidence suggesting the clinical association between serum ferritin concentrations and diabetes, it is not clearly identified in other ethnic groups besides western population. This study analyzed a longitudinal relationship between serum ferritin concentration and the risk for diabetes in non-diabetic Korean men.
Methods:
This study was composed of a cohort of 30,002 non-diabetic Korean men who participated in medical health check-up program in 2005. They were divided into 4 groups according to their baseline ferritin concentrations (first quartile-fourth quartile) and monitored until 2010. Their incidences and hazard ratios of diabetes were compared among 4 groups according to their baseline ferritin concentrations.
Results:
While 2655 cases of diabetes newly developed during follow-up, incidence of diabetes increased proportionally to the baseline serum ferritin concentrations. In Cox-proportional hazard model, hazard ratios for diabetes also independently increased according to the baseline serum ferritin concentrations [quartile 1: 1.00 (reference), quartile 2: 1.00 (0.87-1.12), quartile 3: 1.13 (1.00-1.29), quartile 4: 1.18 (1.04-1.34), respectively].
Conclusions:
Increased ferritin concentration was associated with increased risk for diabetes in Korean men. These findings suggest the clinical significance of serum ferritin concentration in the development diabetes.
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