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Related Experiment Videos

Suicidal risk from TADS study was higher than it first appeared.

Göran Högberg1,2, David O Antonuccio3, David Healy4

  • 1Department of Women's and Children's Health, Child and Adolescent Psychiatric Unit, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden.

The International Journal of Risk & Safety in Medicine
|September 28, 2015
PubMed
Summary

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Selective serotonin reuptake inhibitor (SSRI) use in adolescents may increase suicidal events. The Treatment of Adolescents with Depression Study (TADS) found a significant rise in suicidal behavior among those on medication versus placebo.

Area of Science:

  • Child and Adolescent Psychiatry
  • Neuroscience
  • Public Health

Background:

  • Completed suicides are a significant cause of mortality in adolescents.
  • Forensic analyses indicate a notable incidence of completed suicides among children using selective serotonin reuptake inhibitors (SSRIs).

Purpose of the Study:

  • To investigate suicidal events reported in the Treatment of Adolescents with Depression Study (TADS).
  • To analyze the association between antidepressant medication and suicidal events in adolescents.

Main Methods:

  • Review and analysis of data from the Treatment of Adolescents with Depression Study (TADS).
  • Comparison of suicidal event proportions between adolescents receiving antidepressant medication and those on placebo.
Keywords:
CBTSSRIsTADSadolescent depressionsuicide

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Main Results:

  • A significant increase in suicidal events was observed in adolescents treated with antidepressant medication compared to the placebo group.
  • Suicidal events occurred in 11% of the medication group versus 2.7% in the placebo group.
  • This finding was underreported in the original TADS study.

Conclusions:

  • Antidepressant medication, particularly SSRIs, may be associated with an increased risk of suicidal events in adolescents.
  • The findings suggest a potential link between SSRI use and completed suicides in Swedish adolescents.