Related Experiment Video
Updated: Apr 3, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Procedural intervention for arthrofibrosis after ACL reconstruction: trends over two decades
Thomas L Sanders1, Hilal Maradit Kremers2,3, Andrew J Bryan2
1Departments of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. sanders.thomas@mayo.edu.
Arthrofibrosis after anterior cruciate ligament (ACL) reconstruction is rare, affecting about 2% of patients. Female patients face a higher risk, but interventions are effective for managing post-operative stiffness.
Area of Science:
- Orthopedic Surgery
- Sports Medicine
- Epidemiology
Background:
- Arthrofibrosis is a rare but serious complication following anterior cruciate ligament (ACL) reconstruction.
- It is characterized by significant post-operative joint stiffness and limited range of motion.
- Early identification and intervention are crucial for optimal patient outcomes.
Purpose of the Study:
- To determine the population-based incidence of arthrofibrosis after ACL injury and reconstruction.
- To identify specific risk factors associated with the development of arthrofibrosis.
- To evaluate the effectiveness of interventions for managing arthrofibrosis.
Main Methods:
- A historical cohort study was conducted using the Rochester Epidemiology Project (REP) in Olmsted County, Minnesota.
- The study identified 1841 individuals with new-onset, isolated ACL tears between 1990 and 2010.
- Incidence rates were calculated, and predictive factors including age, sex, and meniscal injury were analyzed.
Main Results:
- The incidence of arthrofibrosis requiring intervention was 1.7% in the ACL reconstruction cohort and 1.0% in the non-operative cohort.
- Female patients demonstrated a 2.5 times higher likelihood of developing arthrofibrosis compared to males.
- Preoperative range of motion improved significantly after surgical intervention.
Conclusions:
- Arthrofibrosis is an uncommon but significant complication after ACL reconstruction, with approximately 2% of patients requiring intervention for stiffness.
- Female sex is identified as a significant risk factor for developing arthrofibrosis.
- Interventions for post-operative motion complications following ACL injury are generally effective in preventing permanent arthrofibrosis.
More Related Videos
05:07Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction
Published on: March 1, 2024
06:28Anterior Cruciate Ligament Transection and Synovial Fluid Lavage in a Rodent Model to Study Joint Inflammation and Posttraumatic Osteoarthritis
Published on: September 2, 2025