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Updated: Apr 3, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Preventing Acute Kidney Injury
Etienne Macedo1, Ravindra L Mehta2
1Department of Medicine, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA; Nephrology Division, University of Sao Paulo, Brazil.
Abstract:
Epidemiologic studies applying the acute kidney injury (AKI) classification system have confirmed the increasing incidence of AKI in different settings and its association with adverse outcomes. AKI is now a recognized important risk factor for new-onset chronic kidney disease, determining acceleration in progression to end-stage renal disease, leading to poor quality of life, disability, and long-term costs. AKI has been associated with high mortalities; however, it is likely that a significant number of deaths associated with AKI could be avoided. This article reviews the key aspects of the 0by25 initiative and its application in critically ill patients.
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