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Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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The radiologically isolated syndrome.

C Lebrun1

  • 1Neurology, Pasteur University Hopital, 30, voie romaine, Nice 06002, France.

Revue Neurologique
|September 28, 2015
PubMed
Summary
This summary is machine-generated.

Radiologically Isolated Syndrome (RIS) identifies individuals at risk for multiple sclerosis (MS). A 5-year conversion rate of 34% to clinical events was observed, with age, male sex, and spinal cord lesions predicting progression.

Keywords:
Clinically isolated syndromeImagerie par résonance magnétiqueMultiple sclerosisRadiologically isolated syndromeResonance imagingSclérose en plaquesSyndrome clinique isoléSyndrome radiologique isolé

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Area of Science:

  • Neurology
  • Radiology
  • Epidemiology

Background:

  • Radiologically Isolated Syndrome (RIS) describes individuals with incidental MRI findings suggestive of multiple sclerosis (MS) but without neurological symptoms.
  • RIS is a subtype of MS characterized by T2 lesions indicative of demyelination, placing individuals at risk for future neurological events.
  • Formal criteria for RIS were established in 2009, defining a cohort at risk for demyelinating disease progression.

Purpose of the Study:

  • To characterize the natural course and risk factors for clinical conversion in individuals with RIS.
  • To identify predictors for the development of the first clinical event in a large cohort of RIS patients.
  • To highlight the need for prospective studies to inform therapeutic strategies for early-stage MS.

Main Methods:

  • Retrospective analysis of data from 451 RIS subjects within the Radiologically Isolated Syndrome Worldwide (RISC) consortium.
  • Longitudinal follow-up to assess clinical conversion rates and identify predictors of neurological events.
  • Multivariate modeling to determine significant risk factors for disease progression.

Main Results:

  • The 5-year conversion rate to a first clinical event in the RIS cohort was 34%.
  • Significant predictors for clinical conversion included age, male sex, and the presence of lesions in the cervical or thoracic spinal cord.
  • Cognitive impairment was observed in a significant proportion of RIS patients compared to healthy controls.

Conclusions:

  • RIS patients have a substantial risk of progressing to symptomatic MS, with specific demographic and radiological factors influencing this risk.
  • Current understanding of RIS natural history and risk profiles requires further investigation through prospective studies.
  • Prospective research is essential to guide the development of early therapeutic interventions for RIS.