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Hypertriglyceridemia in extremely low birth weight infants receiving lipid emulsions

P Holtrop1, T Swails1, T Riggs2

  • 1Department of Pediatrics, William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.

Journal of Neonatal-Perinatal Medicine
|September 28, 2015
PubMed

Insights

High triglyceride levels are common in extremely low birth weight (ELBW) infants. Lower birth weight is a significant risk factor for these elevated triglyceride levels in ELBW infants.

Area of Science:

  • Neonatalogy
  • Pediatric Endocrinology
  • Biochemistry

Background:

  • Extremely low birth weight (ELBW) infants are at risk for metabolic complications.
  • Lipid infusions are crucial for nutrition in ELBW infants but can affect triglyceride levels.

Purpose of the Study:

  • To determine the prevalence of high triglyceride (TG) levels in ELBW infants.
  • To identify risk factors associated with elevated TG levels in this population.

Main Methods:

  • Prospective observational study of 75 ELBW infants receiving escalating lipid infusions.
  • Triglyceride concentrations measured at 1 and 2 grams/kg/day of lipid infusion.
  • Univariate and multivariate analyses compared infants with normal (≤200 mg/dl) versus elevated (>200 mg/dl) TG levels.

Main Results:

  • Twenty infants (26.7%) exhibited elevated triglyceride levels (>200 mg/dl).
  • Lower birth weight was significantly associated with increased risk of high TG levels.
  • Elevated TG levels did not predict subsequent mortality or morbidity.

Conclusions:

  • High triglyceride levels are a common finding in ELBW infants.
  • Lower birth weight is a key risk factor for hypertriglyceridemia in ELBW infants.
  • Further research may explore optimal lipid management strategies for ELBW infants.
Abstract

Keywords:
Neonateslipidstriglyceride concentrations

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