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Updated: Apr 3, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
Hypertriglyceridemia in extremely low birth weight infants receiving lipid emulsions
P Holtrop1, T Swails1, T Riggs2
1Department of Pediatrics, William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
Objective:
To determine the prevalence of high TG levels in extremely low birth weight (ELBW) infants and what the risk factors are for high TG levels.
Study Design:
We performed a prospective observational study of triglyceride concentrations in extremely low birth weight infants receiving lipid infusions. Lipid infusions were begun at 0.5 grams/kg/day at age one day and the dose advanced by 0.5 grams/kg/day. Triglyceride concentrations were drawn when the dose reached 1 and 2 grams/kg/day. We compared infants with normal triglyceride levels (≤200 mg/dl) with those with elevated triglyceride levels (>200 mg/dl) with univariate and multivariate analysis.
Results:
There were 75 infants included in the analysis. Twenty (26.7% , 95% CI = 16.6-36.7%) had triglyceride levels >200 mg/dl. On multiple logistic regression analysis, lower birth weight was associated with the risk of an elevated triglyceride level. Triglyceride levels >200 mg/dl did not predict future mortality or morbidity.
Conclusion:
Elevated TG levels occur commonly in ELBW infants and are associated with a lower birth weight.
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