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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Regulation of Metabolism01:19

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Long Noncoding RNAs: A New Regulatory Code in Metabolic Control.

Xu-Yun Zhao1, Jiandie D Lin1

  • 1Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Trends in Biochemical Sciences
|September 28, 2015
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) regulate gene expression and are key to metabolic tissue development and function. Understanding lncRNA pathways offers new insights into metabolic diseases.

Keywords:
brown fatenergy metabolismlncRNAmetabolic diseasesignalingtranscription

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Area of Science:

  • Genomics
  • Molecular Biology
  • Metabolic Research

Background:

  • Long noncoding RNAs (lncRNAs) are crucial genomic regulators.
  • lncRNAs interact with nucleic acids and proteins, influencing biological processes.
  • Emerging evidence links lncRNAs to metabolic tissue development and function.

Purpose of the Study:

  • To review lncRNA biology.
  • To focus on the role of lncRNAs in metabolic tissues.
  • To explore lncRNA involvement in metabolic disease mechanisms.

Main Methods:

  • Literature review of recent studies on lncRNAs and metabolism.
  • Analysis of lncRNA pathways controlling metabolic tissues.
  • Discussion of genetic and pathogenic mechanisms in metabolic disease.

Main Results:

  • lncRNAs are integral to the genome's regulatory information.
  • Multiple lncRNA pathways controlling metabolic tissues have been identified.
  • lncRNAs provide insights into nutrient and hormonal signaling in metabolism.

Conclusions:

  • lncRNAs play a significant role in the development, signaling, and function of metabolic tissues.
  • Dysregulation of lncRNAs may contribute to metabolic diseases.
  • Further research into lncRNA pathways is essential for understanding metabolic health and disease.