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Updated: Apr 2, 2026

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Published on: October 27, 2014
Rituximab is effective in severe treatment-resistant neurological Behçet's syndrome
D P Kidd1,2
1Department of Clinical Neurosciences, Royal Free Hospital, Pond Street, London, NW3 2QG, UK. d.kidd@ucl.ac.uk.
Abstract:
The objective of this study is to describe a case of severe and treatment-resistant neurological Behçet's syndrome responsive to a novel therapy. This case report describes the patient who failed to respond to conventional therapy but the brain stem lesion resolved with the anti-CD20 biological agent rituximab. Neurological complications are uncommon in Behçet's syndrome; 80% involve a meningoencephalitis which can be severe and relapsing. This is the first report of effectiveness of rituximab in this uncommon disease.
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