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Tribbles 3: A potential player in diabetic aortic remodelling.
Yun Ti1, Guo-lu Xie2, Zhi-hao Wang3
1Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, P.R. China.
Diabetes & Vascular Disease Research
|September 28, 2015
Summary
Tribbles 3 (TRIB3) protein is overexpressed in diabetic aortas, contributing to vascular complications. Silencing TRIB3 reversed aortic remodelling and improved arterial compliance in a type 2 diabetes rat model.
Area of Science:
- Cardiovascular Biology
- Metabolic Diseases
- Molecular Medicine
Background:
- Tribbles 3 (TRIB3) is linked to insulin resistance and diabetic cardiomyopathy.
- The role of TRIB3 in aortic remodeling in diabetes remains unclear.
Purpose of the Study:
- To investigate the role of TRIB3 in aortic vascular remodeling in a type 2 diabetes rat model.
- To assess the therapeutic potential of TRIB3 gene silencing in diabetic aortic complications.
Main Methods:
- A type 2 diabetic rat model was established using a high-fat diet and streptozotocin.
- Aortic characteristics were evaluated using ultrasonography and histopathology.
- Tribbles 3 gene silencing was performed using small interfering RNA (siRNA) in vivo.
Main Results:
- Diabetic rats exhibited increased aortic medial thickness, collagen deposition, reduced elastic fibers, and decreased vascular compliance, alongside TRIB3 overexpression.
- Tribbles 3 gene silencing significantly reversed pathological aortic remodeling, reducing medial thickness and fibrosis.
- Silencing TRIB3 restored PI3K/Akt phosphorylation and decreased MKK4/JNK activation, improving arterial compliance.
Conclusions:
- Tribbles 3 plays a significant role in diabetic aortic remodeling.
- Targeting Tribbles 3 offers a potential therapeutic strategy for vascular complications associated with diabetes.
