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[DYNAMICS OF THE CIRCADIAN BLOOD PRESSURE PROFILE DURING COMBINED AMLODIPINE-VALSARTAN THERAPY IN FAR NORTH
Insights
Combined amlodipine-valsartan therapy effectively normalized daily arterial pressure (AP) profiles in Far North employees with hypertension, regardless of their work schedule. High treatment efficacy and tolerability were observed in both day and night shift workers.
Area of Science:
- Cardiology
- Pharmacology
- Occupational Health
Abstract:
The aim of the work was to study dynamics of daily arterial pressure profile during combined antihypertensive therapy starting from calcium and angiotensin II antagonists (amlodipine-valsartan) in Far North employees suffering arterial hypertension engaged on different working schedules. A total of 137 patients with grade I-III AH were divided into 2 groups. Those in group 1 worked day shifts (n=70) and the remaining ones worked night shifts (group 2). 129 patients completed the course of therapy. The final mean daily doses of amlodipine-valsartan were 8.2 ± 1.1/144.8 1.8 and 9.4 ± 1.6/197.8 ± 3.5 mg in groups I and 2 respectively. AP monitoring was performed before, 4 weeks and 6 months after therapy. Six months after the onset of amlodipine-valsartan therapy 97.2 and 97.6% of the patients in groups 1 and 2 respectively showed the target AP level and normalization of daily AP profile. Daily variability of AP in group 2 (excepting night-time variability) was also normal. Morning AP dynamics markedly improved in both groups. Most patients demonstrated excellent compliance with therapy due to its high efficacy and good tolerability.
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