Related Experiment Video

Updated: Apr 2, 2026

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
09:51

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

2.3K

A Study of Liver Function Tests in leprosy

M Swathi

    Indian Journal of Leprosy
    |September 29, 2015
    PubMed

    Insights

    Leprosy patients show minimal liver function derangement, even with potential drug toxicity. Monitoring liver function tests is crucial before initiating treatment for this chronic granulomatous disease.

    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Clinical Biochemistry

    Background:

    • Leprosy, caused by Mycobacterium leprae, is a chronic disease often affecting the liver.
    • Hepatotoxic drugs used in leprosy treatment can further impair liver function.

    Purpose of the Study:

    • To evaluate the hepatic status in leprosy patients.
    • To compare liver function tests (LFTs) between untreated leprosy patients and healthy controls.

    Main Methods:

    • Study included 30 untreated leprosy patients (18 Multibacillary, 12 Paucibacillary) and 20 healthy controls.
    • Assessed serum levels of bilirubin, ALT, AST, ALP, total protein, albumin, and globulin.
    • Statistical comparison using independent sample 't' test, with P < 0.05 considered significant.

    Main Results:

    • Significant differences observed in most LFT parameters between leprosy patients and controls, except for serum total protein.
    • Indicated minimal derangement in hepatic function among leprosy patients.

    Conclusions:

    • Leprosy patients exhibit minimal hepatic function impairment.
    • Routine monitoring of LFTs is essential for assessing liver health before leprosy treatment initiation.

    More Related Videos

    Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI06:09

    Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

    Published on: July 21, 2023

    2.1K
    Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis06:26

    Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

    Published on: July 18, 2025

    1.1K

    Related Concept Videos

    Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

    Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

    In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
    258
    Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

    Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

    Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
    335
    Liver Histology01:27

    Liver Histology

    The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
    Hepatocytes perform a variety of essential functions. They secrete...
    10.5K
    Serum Laboratory Studies, Stool Test, Breath Test01:30

    Serum Laboratory Studies, Stool Test, Breath Test

    Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
    1.1K
    Liver Physiology01:30

    Liver Physiology

    The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
    Metabolic Regulation:
    The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
    4.2K
    Diseases of the Liver and Gallbladder01:26

    Diseases of the Liver and Gallbladder

    Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
    Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
    2.3K