[Arterial pathology in migraine: endothelial dysfunction and structural changes in the brain and systemic

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Davinia Larrosa-Campo1, César Ramón-Carbajo, Rocío Álvarez-Escudero

  • 1Hospital Universitario Central de Asturias, 33006 Oviedo, Espana.

Revista De Neurologia
|September 29, 2015
PubMed

Insights

Migraine may be linked to early vascular changes due to endothelial dysfunction, a predictor of arterial wall damage. While biomarkers show dysfunction, definitive links to structural arterial changes outside the brain remain unclear.

Area of Science:

  • Vascular Biology
  • Neurology
  • Cardiology

Context:

  • Migraine is a prevalent neurological disorder.
  • The link between migraine and non-atherosclerotic vascular diseases is not well understood.
  • Endothelial dysfunction is a potential common pathway.

Purpose:

  • To review current literature on arterial properties in migraine.
  • To examine functional (endothelial dysfunction) and structural (arterial stiffness, atherosclerotic diseases) aspects.
  • To synthesize findings on vascular pathology associated with migraine.

Summary:

  • Studies indicate increased endothelial dysfunction biomarkers in migraine patients.
  • Vasoreactivity studies show mixed results, preventing firm conclusions.
  • Evidence does not support macroscopic arterial alterations outside the cerebral vasculature in migraine.

Impact:

  • Endothelial dysfunction may serve as an early marker for vascular pathology in migraine.
  • Understanding these links can inform future research on migraine comorbidities.
  • Highlights the need for further investigation into migraine's vascular implications.
Abstract

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