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Clinical application of pharmacogenetics: focusing on practical issues
Matthew T Chang1, Jeanette J McCarthy2,3, Jaekyu Shin4
1Departments of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA.
Pharmacogenomics
|September 29, 2015
Summary
Pharmacogenetics uses genetic information to guide drug selection, dosing, and prevent adverse events. This review addresses practical challenges for clinicians implementing pharmacogenetic testing in patient care.
Area of Science:
- Pharmacogenetics
- Clinical Pharmacology
- Genomic Medicine
Background:
- Large-scale genetic studies have advanced pharmacogenetics, enabling personalized patient care through genetic insights.
- Precision medicine integrates genetic information to optimize therapeutic strategies.
- Clinicians need to effectively utilize pharmacogenetics for improved patient outcomes.
Observation:
- Identifying suitable patients for pharmacogenetic testing is a key challenge.
- Selecting appropriate clinical laboratories and valid testing resources is crucial.
- Navigating reimbursement and interpreting complex genetic test results pose practical hurdles.
Findings:
- This review addresses practical issues in implementing pharmacogenetic testing.
- Key challenges include patient identification, laboratory selection, and resource assessment.
- Interpreting test results and managing costs are also discussed.
Implications:
- Effective implementation of pharmacogenetics can enhance drug selection and dosing.
- Preventing adverse drug events is a significant benefit of pharmacogenetic guidance.
- Overcoming practical challenges is essential for widespread clinical adoption of pharmacogenetics.
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