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Related Concept Videos

The Nucleosome Core Particle02:10

The Nucleosome Core Particle

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
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The Nucleosome Core Particle01:12

The Nucleosome Core Particle

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
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Nucleosome Remodeling02:54

Nucleosome Remodeling

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Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
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The Nucleosome02:33

The Nucleosome

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DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
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The Nucleosome01:19

The Nucleosome

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Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
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The Nucleosome02:33

The Nucleosome

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Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
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Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA

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Nucleosome positioning: resources and tools online.

Vladimir B Teif

    Briefings in Bioinformatics
    |September 29, 2015
    PubMed
    Summary
    This summary is machine-generated.

    This review guides researchers through online resources for nucleosome positioning, covering experimental datasets and computational tools for genome analysis.

    Keywords:
    DNA-protein bindingMNase-seqchromatinepigeneticsgene regulationnucleosome positioning

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    Area of Science:

    • Genomics
    • Molecular Biology
    • Bioinformatics

    Background:

    • Nucleosome positioning is crucial for genome organization and gene regulation.
    • Understanding nucleosome positioning is key to cell-specific genetic program execution.

    Purpose of the Study:

    • To provide a practical guide to online resources for nucleosome positioning.
    • To consolidate information on experimental datasets and computational tools.

    Main Methods:

    • Review of existing literature and online databases.
    • Curation of a list of nucleosome positioning resources.
    • Identification of experimental datasets and computational tools.

    Main Results:

    • Compilation of nearly 300 genome-wide nucleosome occupancy datasets.
    • Identification of over 40 computational tools for data analysis and prediction.
    • Establishment of a manually curated, up-to-date online resource list.

    Conclusions:

    • A comprehensive guide to nucleosome positioning resources is now available online.
    • Facilitates research in genome packing, accessibility, and gene regulation.