Related Experiment Video
Updated: Apr 2, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
An efficient Synthesis and Photophysical Properties of 1H-pyrazolo-[3,4-b]pyridine and
Raviraj Deore1,2, Kunal Dingore1,2, Madhukar Jachak3,4
1Organic Chemistry Research Centre, Department of Chemistry, K.T.H.M. College, Gangapur Road, Nashik, 422002, Maharashtra, India.
Abstract:
A novel synthon 6-amino-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazolo[3,4-b] pyridine-5-carbaldehyde 4 was synthesized by multistep process. Then Friedlander condensation of this synthon with reactive methylenes was performed to achieve interesting tricyclic 6a-b, tetracyclic 6d and pentacyclic 6c N-heterocycles in excellent yield. The absorption and emission spectra of compounds 1-4 and 6 were measured and observed that the absorption and emission depends on the substituent at C-6 and C-7 position of pyridine ring in naphthyridines skeleton 6.
Related Concept Videos
Basicity of Heterocyclic Aromatic Amines
Five-Membered Heterocyclic Aromatic Compounds: Overview
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Variables Affecting Phosphorescence and Fluorescence
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group...

